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Mifepristone and misoprostol (also known as Cytotec) are commonly used medications for medical abortions, particularly for pregnancies up to 6 months gestation.[ These medications work together to terminate the pregnancy - mifepristone blocks the hormone progesterone, while misoprostol causes the uterus to contract and expel the pregnancy .



The effectiveness of using mifepristone and misoprostol simultaneously versus with a 24-hour interval has been studied in randomized controlled trials. These studies have found that the two regimens have similar efficacy, with complete abortion rates around 95-97%. However, the simultaneous administration of the medications may result in slightly more side effects like nausea, diarrhea, and chills compared to the 24-hour interval .



Misoprostol (Cytotec) is typically dosed at 800 mcg administered vaginally for these medical abortion regimens 1. Mifepristone is dosed at 200 mg orally. The Mifegest-kit contains both of these medications packaged together.



It's important to note that the use of these medications for abortion is contraindicated in pregnant women, as they can cause serious complications like uterine rupture ). Patients must be properly counseled on the risks and provided with the necessary information.