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• XANAX is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous

system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression),

coma, and death.

Get emergency help right away if any of the following happens:

• Shallowed or slowed breathing

• Breathing stops (which may lead to the heart stopping)

• Excessive sleepiness (sedation)

Do not drive or operate heavy machinery until you know how taking XANAX with opioids affects you.

• There is a risk of abuse, misuse, and addiction with XANAX, which can lead to overdose and serious side effects, including

coma and death, delirium, paranoia, suicidal thoughts or actions, seizures, and difficulty breathing. You can develop an addiction

even if you take XANAX as prescribed by your healthcare provider.

• XANAX can cause physical dependence and withdrawal reactions. Do not suddenly stop taking XANAX as it may lead to

serious and life-threatening side effects, including unusual movements, responses, or expressions, seizures, sudden and severe

mental or nervous system changes, depression, seeing or hearing things that others do not, an extreme increase in activity or talking,

losing touch with reality, and suicidal thoughts or actions.

CALL YOUR HEALTHCARE PROVIDER OR GO TO THE HOSPITAL EMERGENCY ROOM RIGHT AWAY IF YOU GET ANY OF THE ABOVE

LIFE-THREATENING OR SERIOUS SIDE EFFECTS.

XANAX is a federal controlled substance (C-IV) because it can be abused or lead to dependence. Keep XANAX in a safe place to

prevent misuse and abuse. It is not known if XANAX is safe and effective in children.

Do not take XANAX if you are allergic to alprazolam, other benzodiazepines, or any of the ingredients in XANAX. Do not take XANAX if

you are taking antifungal treatments, including ketoconazole or itraconazole.

Before you take XANAX, tell your healthcare provider about all your medical conditions, including if you:

• Have or have had depression, mood problems, or suicidal thoughts or behavior.

• Have liver or kidney problems.

• Have lung disease or breathing problems.

XANAX is indicated to treat anxiety disorders and for the short-term relief of symptoms of anxiety. XANAX is also indicated to treat panic disorder with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

IMPORTANT SAFETY INFORMATION AND INDICATIONS

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What is the most important information I should know about XANAX?



XANAX is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma, and death.

Get emergency help right away if any of the following happens:

• XANAX is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous

system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression),

coma, and death.

Get emergency help right away if any of the following happens:

• Shallowed or slowed breathing

• Breathing stops (which may lead to the heart stopping)

• Excessive sleepiness (sedation)